Celebrex and its anti-inflammatory drug, paracetamol, have been a game-changer in the fight against arthritis.
The two-day trial, sponsored by the U. S. Food and Drug Administration, is intended to examine the long-term safety of Celebrex, administered for up to 10 days, in more than 100,000 people with osteoarthritis.
The findings, released by the agency in September, are presented at the annual meeting of the American College of Rheumatology in Chicago on Oct. 4, 2010.
The study will include participants who have been on a Celebrex dose of 400 mg or more and have no history of joint pain, inflammation, or other arthritis-related issues.
Researchers recruited about 1,400 patients with osteoarthritis at an average age of 50, and randomly assigned those to receive either Celebrex 200 mg or placebo for 10 days or the usual treatment.
The results of the study were published in the April 2012 issue of theAnnals of Rheumatology. The study included 7,927 participants, with an average age of 49.
In the Celebrex group, researchers found a statistically significant decrease in the amount of cartilage (the lining of bone) in the joint area after treatment, compared to the placebo group. In contrast, in the placebo group, cartilage loss was only seen in around 15% of the participants.
In the Celebrex group, the cartilage loss was less marked in the joint area, compared to the placebo group. In the Celebrex group, cartilage loss was also less marked, in the same areas as those in the placebo group.
The study authors said they are “confident that this is the most likely explanation for the decrease in cartilage in the joint area,” but that “the impact on the joint area should be considered carefully in the future.”
In the Celebrex group, researchers found that the number of participants who took the medication for 12 weeks was significantly greater than placebo in all areas.
However, the researchers said, the number of people who took the medication was lower in the Celebrex group, but that it was still higher in the placebo group. “The data suggests that the effect on the joint area is not due to the number of participants who take the medication but to the reduced number of participants,” said the researchers.
Celebrex was associated with a slight increase in joint pain after 12 weeks on the treatment, with only a small increase in pain intensity.
“It is important that we carefully consider the potential long-term benefits of this drug for the treatment of arthritis, and the need for continued research to evaluate its long-term benefits,” said Dr. Michael J. Johnson, a professor of rheumatology at Harvard Medical School and director of the Rheumatology Section of the Massachusetts General Hospital. “There is a need for further studies to better define the long-term safety and efficacy of this treatment in the future.”
Celebrex, known generically as celecoxib, was approved by the FDA in December 1997.
Johnson and others have warned that “a large number of patients who are taking NSAIDs, like ibuprofen or naproxen, should not be treated with these medications for the treatment of osteoarthritis,” they wrote in their 2014 letter to the FDA.
Celebrex was withdrawn from the market after studies found that it did not affect bone mineral density.
Celebrex’s safety has been under scrutiny by the FDA since 2010, when it was discovered that it could cause a dangerous drop in blood pressure. The agency has asked for a new warning label for Celebrex and is seeking to reassure patients and doctors that it is safe.
The drug, which is available as an over-the-counter product, is also used for pain management and has not been studied in a randomized controlled trial.
The study was conducted by researchers at the National University of Singapore, who did not receive funding for the research, and was funded by Pfizer. A similar trial was conducted at the University of Pennsylvania, where researchers also did not receive funding for the study.
“We believe that the risk of side effects in the study of Celebrex is greater than that found with the placebo,” said Dr. Steven Nissen, a professor of medicine at Harvard Medical School and a principal investigator of the trial.
CELEBREX 200MG CAPSULE contains Celecoxib which belongs to group of medicines called Non-steroidal anti-inflammatory drugs. CELEBREX 200MG CAPSULE is used in adults to manage osteoarthritis (degenerative joint disease), rheumatoid arthritis (inflammatory disease of joints), ankylosing spondylitis (chronic back pain), acute pain and primary dysmenorrhea (menstrual cramps).
CELEBREX 200MG CAPSULE is also used to manage juvenile rheumatoid arthritis (in children aged 2 years and above).
CELEBREX 200MG CAPSULE is not recommended for use in patients allergic to Celecoxib, sulfonamides, aspirin and/or other NSAIDs. It is also not recommended for use in patients with/had a history of an ulcer in stomach/intestines, bleeding in stomach/intestines, blood circulation problems (such as peripheral arterial disease), red itchy welts, inflammatory disease of the intestines (such as ulcerative colitis/Crohn’s disease).
The medicine is also not indicted for use in patients suffering from lung problems (such as asthma), heart diseases (such as heart failure, recent heart attack, heart block), severe liver disease (such as advanced hepatic insufficiency) and/or kidney disease (such as advanced renal insufficiency).
Before taking CELEBREX 200MG CAPSULE, inform your doctor if you have diabetes, raised blood pressure, increased cholesterol, signs of fluid retention (such as swollen ankles and feet) and/or hyperkalemia (increased potassium level in blood).
CELEBREX 200MG CAPSULE is not recommended for use in pregnant and breast-feeding women.
CELEBREX 200MG CAPSULE should be used with caution in children and adolescents (aged 2 to 17 years) to manage only juvenile rheumatoid arthritis and is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.
The most common side effects of taking CELEBREX 200MG CAPSULE are high blood pressure, shortness of breath, sore throat, cough, headache, nausea and dizziness. Consult your doctor if any of these symptoms worsen.
What are the side effects of taking CELEBREX 200MG CAPSULE?A small number of people taking CELEBREX 200MG CAPSULE have reported side effects of eating well and avoiding foods that are known to cause adverse reactions such as spicy foods, alcohol, antacids, coffee, alcohol-containing products and grapefruit juice. Some of the side effects of taking CELEBREX 200MG CAPSULE are (signs include stomach pain, nausea and vomiting.) If you are experiencing any side effects, it is recommended to contact the doctor immediately.
How long have I been taking CELEBREX 200MG CAPSULE?If you are taking CELEBREX 200MG CAPSULE for a long duration, it may be necessary to take it a few times per day to a few days per week.
There is no evidence that taking CELEBREX 200MG CAPSULE for more than 10 days does not result inoculation and reduces the activity of your stated side effect.
How long do I need to have an?No! Even if you have health problems, you can exercise and use limited type of exercise as recommended by the doctor.
The severity of the side effects of taking CELEBREX 200MG CAPSULE is not known. It is recommended to consult with a doctor if any of the side effects are severe.
illCELEBREX 200MG CAPSULE is a prescription medicine.
CELEBREX 200MG CAPSULE contains Celecoxib which belongs to group of medicines called Non-steroidal anti-inflammatory drugs. CELEBREX 200MG CAPSULE is used in adults to manage osteoarthritis (degenerative joint disease), rheumatoid arthritis (inflammatory disease of joints), ankylosing spondylitis (chronic back pain), acute pain and primary dysmenorrhea (menstrual cramps).
CELEBREX 200MG CAPSULE is also used to manage juvenile rheumatoid arthritis (in children aged 2 years and above).
CELEBREX 200MG CAPSULE is not recommended for use in patients allergic to Celecoxib, sulfonamides, aspirin and/or other NSAIDs. It is also not recommended for use in patients with/had a history of an ulcer in stomach/intestines, bleeding in stomach/intestines, blood circulation problems (such as peripheral arterial disease), red itchy welts, inflammatory disease of the intestines (such as ulcerative colitis/Crohn’s disease).
The medicine is also not indicted for use in patients suffering from lung problems (such as asthma), heart diseases (such as heart failure, recent heart attack, heart block), severe liver disease (such as advanced hepatic insufficiency) and/or kidney disease (such as advanced renal insufficiency).
Before taking CELEBREX 200MG CAPSULE, inform your doctor if you have diabetes, raised blood pressure, increased cholesterol, signs of fluid retention (such as swollen ankles and feet) and/or hyperkalemia (increased potassium level in blood).
CELEBREX 200MG CAPSULE is not recommended for use in pregnant and breast-feeding women.
CELEBREX 200MG CAPSULE should be used with caution in children and adolescents (aged 2 to 17 years) to manage only juvenile rheumatoid arthritis and is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.
The most common side effects of taking CELEBREX 200MG CAPSULE are high blood pressure, shortness of breath, sore throat, cough, headache, nausea and dizziness. Consult your doctor if any of these symptoms worsen.
The generic name of CELEBREX 200MG CAPSULE is Celecoxib which belongs to this class of drugs called NSAID).The most common drug side effects of taking CELEBREX 200MG CAPSULE are high blood pressure, shortness of breath, sore throat, cough, headache, nausea and dizziness.
What is NSAID (Celecoxib)? NSAID is an oral medicine used to manage pain and inflammation in conditions like rheumatoid arthritis, osteoarthritis, juvenile rheumatoid arthritis and dysmenorrhea. NSAIDs work by blocking your own production of prostaglandins, which is involved in inflammation and pain. CeleBREX 200MG CAPSULE contains Celecoxib which belongs to the group ofubricants. Celecoxib is an NSAID that works by inhibiting the production of prostaglandins. So, when you have pain, swelling or difficulty breathing, help your immune system to fight the infection. NSAIDs can help with the relief of pain and inflammation from conditions like rheumatoid arthritis, osteoarthritis, juvenile rheumatoid arthritis and dysmenorrhea.How does CELEBREX 200MG CAPSULE work ( Celecoxib)?, And how should I take CELEBREX 200MG CAPSULE?| Active ingredient | Active metabolite | ISolder of Celecoxib |
|---|---|---|
| Celecoxib | Celecoxib belongs to the group of medicines called Non-steroidal anti-inflammatory drugs and is used to manage osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile rheumatoid arthritis and dysmenorrhea. It is prescribed for use in children (12 years of age and older). | |
| S Celecoxib | S Celecoxib belongs to the group of medicines called S-selective COX-2 inhibitors and works by blocking the action of cyclic guanosine monophosphate (cGMP) which is a mediator in the production and release of nitric oxide (NO) in the body. |
Celebrex belongs to the selective COX-2 inhibitors (selective inhibitors). It is used to treat symptoms caused by chronic noninflammatory conditions of the stomach and intestines, such as Crohn’s disease, ulcerative colitis, peptic ulcers, and duodenal ulcers. Celebrex is also used in combination with other medicines to relieve gastrointestinal (GI) symptoms caused by the inflammatory and ulcerative diseases. It is used to treat a condition called Crohn’s disease and the symptoms of ulcerative colitis, as well as to treat the symptoms of ulcerative colitis in patients who are at risk of developing the condition.
Celebrex (Celecoxib) works by blocking the COX-2 enzyme, COX-1. It does not block the activity of prostaglandins. These prostaglandins are responsible for regulating blood flow, pain, and inflammation. This inhibition of COX-1 results in the inhibition of the production of prostaglandins in the GI tract.
Celebrex is available in the form of tablets and capsules.
Celebrex is a selective COX-2 inhibitor. It works by blocking the COX-1 enzyme. By blocking COX-1, Celebrex reduces the production of prostaglandins by the stomach.
Celebrex is taken orally.
Common side effects of Celebrex may include stomach pain, indigestion, upset stomach, diarrhea, constipation, headache, back pain, and muscle pain. These side effects usually go away on their own within a few days. If you experience any of these side effects, stop taking Celebrex and seek medical help right away. Some people may also experience allergic reactions to Celebrex. If you have any of these signs or symptoms, stop taking Celebrex and contact your doctor right away. They may want to schedule a blood test so you can determine whether to take Celebrex.
Before starting Celebrex, tell your doctor if you have a history of stomach ulcers or bleeding problems. Celebrex can cause bleeding or stomach bleeding. Before taking Celebrex, tell your doctor if you have ever had:
Celebrex can cause side effects.
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